Multiple ways of C/EBPalpha inhibition in myeloid leukaemia.
Eur J Cancer
; 44(11): 1516-23, 2008 Jul.
Article
en En
| MEDLINE
| ID: mdl-18515086
ABSTRACT
Transcription factors play a crucial role in myeloid differentiation and lineage determination. Tumour suppressor protein C/EBPalpha is a key regulator of granulocytic differentiation whose functional inactivation has become a pathophysiological signature of myeloid leukaemia. In this review we describe various mechanisms such as antagonistic protein-protein interaction, mutation and posttranslational modifications of C/EBPalpha which lead to its transcriptional inhibition and render C/EBPalpha inactive in its functions.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide
/
Proteína alfa Potenciadora de Unión a CCAAT
/
Mutación
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Eur J Cancer
Año:
2008
Tipo del documento:
Article