Down regulation of immuno-detectable cardiac connexin-43 in BALB/c mice following acute fasting.
Int J Cardiol
; 136(1): 99-102, 2009 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-18606469
ABSTRACT
Acute starvation effects for connexin-43 protein expression, in the heart, had not been previously explored. Hence we examined acute fasting on the myocardial immuno-histochemical expression of connexin-43 in 3 groups of 8-week old female BALB/c mice. Groups consisted of control mice (n=5), fasting for 24 h (N=5) and 48 h (N=3). Under light microscopy all control fed cases revealed the presence of some immuno-detectable staining for connexin-43 that is either present or weakly observed in some or all of the regions of interest, that include the cross-sectional left ventricular sub-endocardium, mid-myocardium and papillary muscle. Whereas mice that underwent 24 or 48 h of acute starvation, connexin-43 expression was either difficult to detect visually (N=3) or was completely absent (N=5) at 40x magnification using a light microscope. In starved mice with no membrane staining for connexin-43 we observed an increase in the intracellular accumulation of cytoplasmic connexin-43 expression.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Regulación hacia Abajo
/
Ayuno
/
Conexina 43
/
Miocitos Cardíacos
Idioma:
En
Revista:
Int J Cardiol
Año:
2009
Tipo del documento:
Article