Reduction in rat oocyte fertilizability mediated by S-(1, 2-dichlorovinyl)-L-cysteine: a trichloroethylene metabolite produced by the glutathione conjugation pathway.
Bull Environ Contam Toxicol
; 81(5): 490-3, 2008 Nov.
Article
en En
| MEDLINE
| ID: mdl-18679558
ABSTRACT
Trichloroethylene (TCE), a commonly used industrial degreasing solvent and environmental toxicant, reduces rat oocyte fertilizability by an incompletely understood mechanism. Previous evidence implicated cytochrome P450 dependent oxidation of TCE. The current study investigated a second pathway, glutathione conjugation using S-(1,2-dichlorovinyl)-L-cysteine (DCVC), a mutagenic and cytotoxic TCE-metabolite. In vitro exposure of oocytes and in vivo exposure of females to DCVC significantly reduced oocyte fertilizability (63% vs. 26%; p < 0.005 and 60% vs. 36%; p < 0.005, respectively). Reduced fertilizability of oocytes following in vivo TCE exposure may be mediated partially by the glutathione conjugation pathway.
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1
Base de datos:
MEDLINE
Asunto principal:
Oocitos
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Tricloroetileno
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Fertilización In Vitro
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Cisteína
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Glutatión
Idioma:
En
Revista:
Bull Environ Contam Toxicol
Año:
2008
Tipo del documento:
Article