Overall type I error rate and power of multiple Dunnett's tests on rodent body weights in toxicology studies.
J Biopharm Stat
; 18(5): 883-900, 2008.
Article
en En
| MEDLINE
| ID: mdl-18781523
ABSTRACT
Body weight data are routinely collected in in vivo general toxicology studies, including 2-year carcinogenicity studies, to help assess the overall health of animals. The effect of the compound on body weight is statistically evaluated for each sex separately using a linear trend test or a many-to-one test by Dunnett. These tests are performed either in the framework of a one-factor analysis of variance (ANOVA) or a repeated measures ANOVA. The one-factor ANOVA with Dunnett's test at each time point is a common practice in industry. Although each individual test is conducted at the 0.05 significance level, one wonders about the overall type I error rate and power for performing many individual Dunnett's tests. A simulation study is conducted to answer this question for general toxicology studies of durations 1 month, 3 months, and 2 years. These results provide guidance to managing multiplicity of body weight analysis of general toxicology studies.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Toxicología
/
Peso Corporal
/
Interpretación Estadística de Datos
Tipo de estudio:
Guideline
Idioma:
En
Revista:
J Biopharm Stat
Asunto de la revista:
FARMACOLOGIA
Año:
2008
Tipo del documento:
Article