AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.
Cell
; 135(6): 1028-38, 2008 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-19070574
ABSTRACT
Chromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and is found in Burkitt's lymphomas in humans and plasmacytomas in mice. DNA breaks in IgH leading to c-myc/IgH translocations are created by activation-induced cytidine deaminase (AID) during antibody class switch recombination or somatic hypermutation. However, the source of DNA breaks at c-myc is not known. Here, we provide evidence for the c-myc promoter region being required in targeting AID-mediated DNA damage to produce DSBs in c-myc that lead to c-myc/IgH translocations in primary B lymphocytes. Thus, in addition to producing somatic mutations and DNA breaks in antibody genes, AID is also responsible for the DNA lesions in oncogenes that are required for their translocation.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Translocación Genética
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Genes myc
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Citidina Desaminasa
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Genes de las Cadenas Pesadas de las Inmunoglobulinas
Idioma:
En
Revista:
Cell
Año:
2008
Tipo del documento:
Article