Determinants and prognostic implications of reperfusion injury during primary percutaneous coronary intervention in Chinese patients with acute myocardial infarction.
Clin Cardiol
; 32(3): 148-53, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19301290
ABSTRACT
BACKGROUND:
The poor clinical outcome in acute myocardial infarction (AMI) patients undergoing primary percutaneous coronary intervention (PCI) has been attributed to myocardial ischemia-reperfusion injury (MIRI).OBJECTIVE:
This study aimed to identify the predictive factors of MIRI during PCI in Chinese AMI patients with or without ST-segment elevation.METHODS:
Clinical and angiographic data of 228 patients in whom the infarct-related artery (IRA) was successfully recanalized by primary PCI were retrospectively analyzed. Multiple logistic regressions were used.RESULTS:
Compared with non-MIRI group (n=109), patients with MIRI (n=119) were characterized by more inferior infarct location, shorter ischemic duration, more frequently right coronary artery as IRA, more lesion vessels, more often thrombolysis in myocardial infarction (TIMI) 0 flow in IRA prior to PCI, less preinfarction angina, and more renal insufficiency. Ischemic timeCONCLUSIONS:
The factors promoting MIRI during primary PCI includes short ischemic time from AMI onset to IRA recanalization, inferior infarct location, low IRA antegrade flow prior to PCI, multivessel lesions, and renal insufficiency, whereas preinfarction angina is a protective factor attenuating MIRI.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Angioplastia Coronaria con Balón
/
Infarto del Miocardio
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Clin Cardiol
Año:
2009
Tipo del documento:
Article