[Relationship between cellular immune response and apoptosis of the brain neurons after brain trauma in rats].
Nan Fang Yi Ke Da Xue Xue Bao
; 29(3): 497-9, 2009 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-19304535
ABSTRACT
OBJECTIVE:
To investigate the relation between CD4(+) and CD8(+) T lymphocyte infiltration and apoptosis of the neurons in the local traumatic brain tissue after brain trauma in rats.METHODS:
In rat models of brain trauma, the changes in the number of CD4(+) and CD8(+) T lymphocytes and the apoptosis of neurons in the local traumatic brain tissue were observed by immunohistochemistry at different time points after brain trauma.RESULTS:
Twenty-four hours after brain trauma, a significant increase in the number of CD4(+) and CD8(+) T lymphocytes occurred in the injured brain tissue, both reaching the highest levels on day 10, at the point of which the number of CD4(+) cells increased by about 15 folds and that of CD8(+) cells by about 20 folds compared with the control groups. The CD4(+) and CD8(+) T lymphocytes both began to decrease 30 days after the injury. A similar pattern of alterations was found in the apoptosis of neurons in the local brain tissue. Correlation analysis demonstrated a close positive correlation between the changes in CD4(+) and CD8(+) lymphocyte numbers and the number apoptotic neurons in the injured brain tissue.CONCLUSIONS:
Brain trauma induces obvious increases in CD4(+) and CD8(+) T lymphocytes and enhanced cellular immune response in the injured brain tissue to mediate neuronal apoptosis and further exacerbate the brain tissue injuries.
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Base de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Linfocitos T CD4-Positivos
/
Apoptosis
/
Linfocitos T CD8-positivos
/
Neuronas
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2009
Tipo del documento:
Article