Role of IL-23-Th17 cell axis in allergic airway inflammation.
Int Arch Allergy Immunol
; 149 Suppl 1: 108-12, 2009.
Article
en En
| MEDLINE
| ID: mdl-19494515
ABSTRACT
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness to a variety of stimuli. It is now generally accepted that antigen-specific Th2 cells and their cytokines orchestrate these pathognomonic features of asthma. On the other hand, Th17 cells and IL-23, a cytokine that preferentially expands Th17 cells, play a significant role in the development of chronic inflammatory diseases, including autoimmune diseases. Recently, we have shown that IL-23 and Th17 cells enhance not only neutrophilic airway inflammation but also Th2 cell-mediated eosinophilic airway inflammation in a murine asthma model. In this review, we will discuss the roles of IL-23 and Th17 cells in airway inflammation in asthma.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Asma
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Subgrupos de Linfocitos T
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Linfocitos T Colaboradores-Inductores
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Interleucina-17
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Interleucina-23
Idioma:
En
Revista:
Int Arch Allergy Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2009
Tipo del documento:
Article