Urgency-free time interval as primary endpoint for evaluating the outcome of a randomized OAB treatment.
Int Urogynecol J Pelvic Floor Dysfunct
; 20(7): 819-25, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19495544
ABSTRACT
INTRODUCTION AND HYPOTHESIS:
This study was conducted to determine whether urgency-free interval (UFI) was effective to evaluate the outcome of overactive bladder (OAB) and the correlation of changes between this parameter and urgency episodes.METHODS:
A randomized placebo-controlled trial was conducted involving 73 women with OAB. The interventions for a 12-week period included a vaginal electric stimulation and oxybutynin (2.5 mg) or placebo three times per day. Identical preintervention and postintervention assessments included the measurement of UFI and warning time (WT). The King's Health Questionnaire, Spearman's correlation coefficient (SCC), Kruskal-Wallis, Mann-Whitney U, and Wilcoxon-signed rank tests were used for analysis.RESULTS:
A positive and significant correlation between the improvements of WT and UFI was noted in the oxybutynin group (p = 0.009). In all groups, none of the SCC revealed significant correlation between the improvement of UFI and urgency episodes (all p >or= 0.145).CONCLUSIONS:
The efficacy of UFI in evaluating treatment outcome of OAB was comparable with that of WT in selected modality.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Parasimpatolíticos
/
Terapia por Estimulación Eléctrica
/
Determinación de Punto Final
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Vejiga Urinaria Hiperactiva
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Incontinencia Urinaria de Urgencia
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Ácidos Mandélicos
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Incidence_studies
/
Prognostic_studies
Idioma:
En
Revista:
Int Urogynecol J Pelvic Floor Dysfunct
Asunto de la revista:
GINECOLOGIA
/
UROLOGIA
Año:
2009
Tipo del documento:
Article