Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study.
BMJ
; 338: b2307, 2009 Jun 24.
Article
en En
| MEDLINE
| ID: mdl-19553269
ABSTRACT
OBJECTIVES:
To assess whether the mortality benefit from screening men aged 65-74 for abdominal aortic aneurysm decreases over time, and to estimate the long term cost effectiveness of screening.DESIGN:
Randomised trial with 10 years of follow-up.SETTING:
Four centres in the UK. Screening and surveillance was delivered mainly in primary care settings, with follow-up and surgery offered in hospitals.PARTICIPANTS:
Population based sample of 67 770 men aged 65-74.INTERVENTIONS:
Participants were individually allocated to invitation to ultrasound screening (invited group) or to a control group not offered screening. Patients with an abdominal aortic aneurysm detected at screening underwent surveillance and were offered surgery if they met predefined criteria. MAIN OUTCOMEMEASURES:
Mortality and costs related to abdominal aortic aneurysm, and cost per life year gained.RESULTS:
Over 10 years 155 deaths related to abdominal aortic aneurysm (absolute risk 0.46%) occurred in the invited group and 296 (0.87%) in the control group (relative risk reduction 48%, 95% confidence interval 37% to 57%). The degree of benefit seen in earlier years of follow-up was maintained in later years. Based on the 10 year trial data, the incremental cost per man invited to screening was pound100 (95% confidence interval pound82 to pound118), leading to an incremental cost effectiveness ratio of pound7600 ( pound5100 to pound13,000) per life year gained. However, the incidence of ruptured abdominal aortic aneurysms in those originally screened as normal increased noticeably after eight years.CONCLUSIONS:
The mortality benefit of screening men aged 65-74 for abdominal aortic aneurysm is maintained up to 10 years and cost effectiveness becomes more favourable over time. To maximise the benefit from a screening programme, emphasis should be placed on achieving a high initial rate of attendance and good adherence to clinical follow-up, preventing delays in undertaking surgery, and maintaining a low operative mortality after elective surgery. On the basis of current evidence, rescreening of those originally screened as normal is not justified. Trial registration Current Controlled Trials ISRCTN37381646.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Rotura de la Aorta
/
Aneurisma de la Aorta Abdominal
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Health_economic_evaluation
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
BMJ
Asunto de la revista:
MEDICINA
Año:
2009
Tipo del documento:
Article