Dysfunctions of neuronal and glial intermediate filaments in disease.
J Clin Invest
; 119(7): 1814-24, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19587456
ABSTRACT
Intermediate filaments (IFs) are abundant structures found in most eukaryotic cells, including those in the nervous system. In the CNS, the primary components of neuronal IFs are alpha-internexin and the neurofilament triplet proteins. In the peripheral nervous system, a fifth neuronal IF protein known as peripherin is also present. IFs in astrocytes are primarily composed of glial fibrillary acidic protein (GFAP), although vimentin is also expressed in immature astrocytes and some mature astrocytes. In this Review, we focus on the IFs of glial cells (primarily GFAP) and neurons as well as their relationship to different neurodegenerative diseases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Filamentos Intermedios
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Neuroglía
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Enfermedades Neurodegenerativas
/
Neuronas
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
J Clin Invest
Año:
2009
Tipo del documento:
Article