Microstructural white matter changes in metabolic syndrome: a diffusion tensor imaging study.
Neurology
; 73(6): 438-44, 2009 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-19667318
ABSTRACT
BACKGROUND:
Although metabolic syndrome is associated with cardiovascular disease and stroke, limited information is available on specific brain damage in patients with this syndrome. We investigated the relationship of the syndrome with white matter (WM) alteration using a voxel-based approach with diffusion tensor imaging (DTI).METHODS:
We compared fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements of DTI in 19 patients with metabolic syndrome aged between 50 and 80 years and 19 age-matched controls without any vascular risk factors for the syndrome.RESULTS:
Patients with metabolic syndrome showed an anterior-posterior pattern of deterioration in WM with reduced FA and increased ADC values compared with controls. WM changes were not related to any isolated vascular risk factor.CONCLUSION:
Although the mechanism of this damage is not clear, the results indicate microstructural white matter alterations in patients with metabolic syndrome, mainly involving the frontal lobe.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome Metabólico
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Imagen de Difusión por Resonancia Magnética
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Fibras Nerviosas Mielínicas
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
Idioma:
En
Revista:
Neurology
Año:
2009
Tipo del documento:
Article