Inflammation, immunity, and vaccines for Helicobacter pylori.
Helicobacter
; 14 Suppl 1: 21-8, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19712164
ABSTRACT
Helicobacter pylori infects almost half of the population worldwide and represents the major cause of gastroduodenal diseases, such as duodenal and gastric ulcer, gastric adenocarcinoma, autoimmune gastritis, and B-cell lymphoma of mucosa-associated lymphoid tissue. Helicobacter pylori induces the activation of a complex and fascinating cytokine and chemokine network in the gastric mucosa. Different bacterial and environmental factors, other concomitant infections, and host genetics may influence the balance between mucosal tolerance and inflammation in the course of H. pylori infection. An inverse association between H. pylori prevalence and the frequencies of asthma and allergies was demonstrated, and the neutrophil activating protein of H. pylori was shown to inhibit the allergic inflammation of bronchial asthma. During the last year, significant progress was made on the road to the first efficient vaccine for H. pylori that will represent a novel and very important bullet against both infection and gastric cancer.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacunas Bacterianas
/
Helicobacter pylori
/
Infecciones por Helicobacter
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Helicobacter
Asunto de la revista:
BACTERIOLOGIA
Año:
2009
Tipo del documento:
Article