Differently selected D-enantiomeric peptides act on different Abeta species.
Rejuvenation Res
; 13(2-3): 202-5, 2010.
Article
en En
| MEDLINE
| ID: mdl-19954333
ABSTRACT
Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (Abeta) forms and insoluble plaques, mainly composed of Abeta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, Abeta-binding peptides D1 and D3. D1 was selected against aggregated Abeta species to address diagnosis by in vivo imaging of amyloid plaques, whereas D3 was selected using low-molecular-weight Abeta species, therefore addressing therapeutical studies. Here, we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Fragmentos de Péptidos
/
Péptidos beta-Amiloides
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Rejuvenation Res
Asunto de la revista:
FISIOLOGIA
/
GERIATRIA
Año:
2010
Tipo del documento:
Article