Prevalence of gastroduodenal mucosal injury in asymptomatic patients taking antiplatelet agents in Japan.
Int J Clin Pharmacol Ther
; 47(12): 722-5, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19954710
ABSTRACT
PURPOSE:
There is little knowledge regarding the prevalence of mucosal injury (MI) in Japanese patients receiving antiplatelet therapy. This study estimated the prevalence of gastroduodenal MI in asymptomatic Japanese patients taking antiplatelet agents and nonsteroidal anti-inflammatory drugs (NSAIDs).METHODS:
Among patients who underwent an upper gastrointestinal endoscopy at Teikyo University Hospital (Tokyo, Japan), 382 asymptomatic patients taking either low-dose aspirin, ticlopidine, cilostazol, or other NSAIDs and 119 people not taking any of these agents were included. Endoscopic records were evaluated for the presence of MI.RESULTS:
Aspirin and NSAIDs users showed a higher prevalence of MI than controls (Aspirin, OR = 2.6 (95% CI = 1.4 - 4.9), NSAIDs, 2.9 (1.4 - 4.4)). Concomitant use of aspirin and NSAIDs increased the prevalence of MI (11.2 (2.8 - 44.8)). Ticlopidine and cilostazol were less likely to cause injury than aspirin and other NSAIDs, the difference remained insignificant due to small sample number (ticlopidine, 0.8 (0.2 - 4.0), cilostazol, 1.3 (0.3 - 4.8)).CONCLUSIONS:
In asymptomatic Japanese patients receiving low-dose aspirin, the prevalence of the gastroduodenal MI was the same as that in patients taking NSAIDs and higher than that in controls.
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Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Agregación Plaquetaria
/
Antiinflamatorios no Esteroideos
/
Duodenitis
/
Gastritis
/
Hemorragia Gastrointestinal
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Int J Clin Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2009
Tipo del documento:
Article