Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.

Gleave, Robert J; Beswick, Paul J; Brown, Andrew J; Giblin, Gerard M P; Goldsmith, Paul; Haslam, Carl P; Mitchell, William L; Nicholson, Neville H; Page, Lee W; Patel, Sadhana; Roomans, Susan; Slingsby, Brian P; Swarbrick, Martin E

Gleave, Robert J; Beswick, Paul J; Brown, Andrew J; Giblin, Gerard M P; Goldsmith, Paul; Haslam, Carl P; Mitchell, William L; Nicholson, Neville H; Page, Lee W; Patel, Sadhana; Roomans, Susan; Slingsby, Brian P; Swarbrick, Martin E.

Afiliación

Gleave RJ; Pain and Neuroexcitability Discovery Performance Unit, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Cold Harbour Lane, Harlow, Essex CM19 5AW, United Kingdom. robert.j.gleave@gsk.com

Bioorg Med Chem Lett ; 20(2): 465-8, 2010 Jan 15.

Article en En | MEDLINE | ID: mdl-20005703

Asunto(s)

Antiinflamatorios/síntesis química; Isoquinolinas/síntesis química; Piridazinas/síntesis química; Receptor Cannabinoide CB2/agonistas; Animales; Antiinflamatorios/química; Antiinflamatorios/farmacocinética; Isoquinolinas/química; Isoquinolinas/farmacocinética; Dolor/tratamiento farmacológico; Piridazinas/química; Piridazinas/farmacocinética; Ratas; Receptor Cannabinoide CB2/metabolismo; Relación Estructura-Actividad

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piridazinas / Receptor Cannabinoide CB2 / Isoquinolinas / Antiinflamatorios Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2010 Tipo del documento: Article

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