Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease.
AJNR Am J Neuroradiol
; 31(4): 711-9, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20037137
ABSTRACT
BACKGROUND AND PURPOSE:
VBM is increasingly used in the study of neurodegeneration, and recently there has been interest in its potential as a biomarker. However, although it is largely "automated," VBM is rarely implemented consistently across studies, and changing user-specified options can alter the results in a way similar to the very biologic differences under investigation. MATERIALS ANDMETHODS:
This work uses data from patients with HD to demonstrate the effects of several user-specified VBM parameters and analyses type and level of statistical correction, modulation, smoothing kernel size, adjustment for brain size, subgroup analysis, and software version.RESULTS:
The results demonstrate that changing these options can alter results in a way similar to the biologic differences under investigation.CONCLUSIONS:
If VBM is to be useful clinically or considered for use as a biomarker, there is a need for greater recognition of these issues and more uniformity in its application for the method to be both reproducible and valid.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
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Encéfalo
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Imagen por Resonancia Magnética
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Enfermedad de Huntington
Tipo de estudio:
Diagnostic_studies
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Observational_studies
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Año:
2010
Tipo del documento:
Article