[Rol of pituitary tumour-transforming gene (PTTG) in the pituitary adenomas]. / Papel de pituitary tumour-transforming gene (PTTG) en los adenomas hipofisarios.
Endocrinol Nutr
; 57(1): 28-34, 2010 Jan.
Article
en Es
| MEDLINE
| ID: mdl-20172484
ABSTRACT
The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Hipofisarias
/
Proteínas de Neoplasias
Idioma:
Es
Revista:
Endocrinol Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
ENDOCRINOLOGIA
Año:
2010
Tipo del documento:
Article