Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries.
J Appl Oral Sci
; 18(2): 166-70, 2010.
Article
en En
| MEDLINE
| ID: mdl-20485928
ABSTRACT
OBJECTIVE:
The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. MATERIAL ANDMETHODS:
A convenience sample of 110 individuals, 12 years old, was divided into group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience (DMFT>or=1). DNA was obtained from a mouthwash with 3% glucose solution, followed by a scrapping of the oral mucosa. After DNA purification, polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) was performed to access the study polymorphism. The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1.RESULTS:
Allele 1 of the study polymorphism was associated with low DMFT index and showed a protective effect against caries experience (OR=0.16, IC=0.03-0.76, p=0.01).CONCLUSIONS:
Lactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with susceptibility to dental caries in 12-year-old students.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Caries Dental
/
Susceptibilidad a Caries Dentarias
/
Lactoferrina
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Appl Oral Sci
Asunto de la revista:
ODONTOLOGIA
Año:
2010
Tipo del documento:
Article