Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval.
J Neurosci
; 30(23): 8001-11, 2010 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-20534848
ABSTRACT
Insulin signaling plays a prominent role in regulation of dauer formation and longevity in Caenorhabditis elegans. Here, we show that insulin signaling also is required in benzaldehyde-starvation associative plasticity, in which worms pre-exposed to the odor attractant benzaldehyde in the absence of food subsequently demonstrate a conditioned aversion response toward the odorant. Animals with mutations in insulin-related 1 (ins-1), abnormal dauer formation 2 (daf-2), and aging alteration 1 (age-1), which encode the homolog of human insulin, insulin/IGF-1 receptor, and PIP3 kinase, respectively, demonstrated significant deficits in benzaldehyde-starvation associative plasticity. Using a conditional allele, we show that the behavioral roles of DAF-2 signaling in associative plasticity can be dissociated, with DAF-2 signaling playing a more significant role in the memory retrieval than in memory acquisition. We propose DAF-2 signaling acts as a learning-specific starvation signal in the memory acquisition phase of benzaldehyde-starvation associative plasticity but functions to switch benzaldehyde-sensing amphid wing C neurons into an avoidance signaling mode during memory retrieval.
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Base de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
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Transducción de Señal
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Caenorhabditis elegans
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Proteínas de Caenorhabditis elegans
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Insulina
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Memoria
Idioma:
En
Revista:
J Neurosci
Año:
2010
Tipo del documento:
Article