Mitochondrial injury and protection in ischemic pre- and postconditioning.
Antioxid Redox Signal
; 14(5): 881-91, 2011 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-20615074
ABSTRACT
Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of the mitochondrial permeability transition pore. The formation of reactive oxygen species in mitochondria will be analyzed with regard to factors controlling mitochondrial permeability transition pore opening. Finally, these mitochondrial processes are analyzed with respect to cardioprotection afforded by ischemic pre- and postconditioning.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Precondicionamiento Isquémico Miocárdico
/
Mitocondrias Cardíacas
Idioma:
En
Revista:
Antioxid Redox Signal
Asunto de la revista:
METABOLISMO
Año:
2011
Tipo del documento:
Article