Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.
Clin Cancer Res
; 16(14): 3754-9, 2010 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-20628028
ABSTRACT
PURPOSE:
To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival. EXPERIMENTALDESIGN:
To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.RESULTS:
None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.CONCLUSIONS:
We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Neoplasias Colorrectales
/
Predisposición Genética a la Enfermedad
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Clin Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2010
Tipo del documento:
Article