[Epithelio-mesenchymal transition and cutaneous wound healing]. / Transition épithélio-mésenchymateuse et réparation des blessures cutanées.
Bull Acad Natl Med
; 193(9): 1981-91; discussion 1992, 2009 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-20666012
ABSTRACT
Successful cutaneous wound repair involves in a series of tightly coordinated and overlapping phases, including inflammation and clot formation, keratinocyte activation and migration (re-epithelialization), basement membrane and ECM remodeling, followed by dermal and epidermal maturation. We examine here the process of wound re-epithelialization, emphasizing the similarity between re-epithelialization and developmental epithelial-mesenchymal transition (EMT), based on morphological and molecular criteria. Changes in cell-cell and cell-substrate adhesion during re-epithelialization are also reminiscent of pathological processes described during malignant tumor progression, another situation involving partial or total EMT. We therefore propose that wound re-epithelialization represents a partial and reversible form of EMT.
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Base de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Epitelio
/
Mesodermo
Idioma:
Fr
Revista:
Bull Acad Natl Med
Año:
2009
Tipo del documento:
Article