Human papillomavirus in ameloblastoma.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 110(3): e20-4, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20727492
ABSTRACT
OBJECTIVE:
Ameloblastomas are benign epithelial tumors of odontogenic origin, with a high recurrence rate and local aggressiveness. A few preliminary studies have demonstrated HPV presence mainly in peripheral ameloblastomas. The purpose of this study was to detect HPV-DNA in intraosseous ameloblastomas.METHODS:
Eighteen cases of intraosseous ameloblastomas of different histological variants were selected. Immunohistochemistry, CISH, nested-PCR, and INNOLiPA HPV Genotyping v2 were used.RESULTS:
The predominant age group was between the third and fourth decades of life. Males were more affected with 61% and females represented 39%. Of the 18 cases, 7 were solid multicystic tumors and 11 were unicystic. Of the histological variants, the plexiform represented 3 (17%) of the 18, 2 (11%) were follicular, 2 (11%) were acanthomatous, and 1 (6%) was desmoplastic. All cases were HPV negative by immunohistochemistry and CISH. HPV-DNA was detected in 6 (33%) of the cases by nested-PCR. HPV 6 was the most frequent genotype in 4 (66%) of the 6. Two cases presented a mixture of HPV 16, 33, and HPV 6, 42 respectively. Four of the unicystic ameloblastomas were HPV positive; of these, all presented koilocytic changes and were associated with dentigerous cysts, whereas only 2 positive cases corresponded to solid ameloblastomas. None of the positive cases were related to recurrence rate.CONCLUSIONS:
We may conclude that HPV low and high risk was detected in our sample of intraosseous ameloblastomas. HPV positivity was observed more in the unicystic cases than solid types.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ameloblastoma
/
Neoplasias Mandibulares
/
Infecciones por Papillomavirus
/
Alphapapillomavirus
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Asunto de la revista:
ODONTOLOGIA
Año:
2010
Tipo del documento:
Article