Challenges facing quantification of rat locomotion along beams of varying widths.
Proc Inst Mech Eng H
; 224(11): 1257-65, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21218688
ABSTRACT
Optoelectronic motion capture systems have been widely used to investigate temporal gait parameters in humans and animals in order to understand function and behavioural attributes of different pathologies, e.g. Parkinson's disease (PD). The aim of the present paper was to investigate the practicality of utilising this system to investigate the effects of a unilateral 6-hydroxydopamine (6-OHDA) lesion on rat locomotion while walking on beams of varying widths (graduated, narrow, and wide). Temporal gait parameters of ten male Lister Hooded rats (five controls and five hemiparkinsonian) were observed using passive markers placed in locations that were representative of their four limbs and their body axis. The results demonstrate that marker-based motion capture can provide an effective and simple approach to quantifying temporal gait parameters for rat models of PD. They also reveal how the width of the path affects the locomotion in both experimental cohorts. Such measurements can be compared with human motion analysis to explore correlations between the animal model and human behaviour, which is an important step for translational medicine.
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Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Grabación en Video
/
Procesamiento de Imagen Asistido por Computador
/
Modelos Animales de Enfermedad
/
Locomoción
Idioma:
En
Revista:
Proc Inst Mech Eng H
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2010
Tipo del documento:
Article