Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block?
Muscle Nerve
; 43(4): 537-42, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21305570
ABSTRACT
INTRODUCTION:
Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)?METHODS:
We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was measured at weeks 2 and 18 using the Appel Amyotrophic Lateral Sclerosis (AALS) score (includes grip and pincer strength measures), ALS Functional Rating Scale (ALSFRS), and electrophysiological measures, including motor unit estimates (MUNEs).RESULTS:
No change occurred in AALS or ALSFRS scores posttreatment. Grip/pincer strength increased in 7 patients (P = 0.028) after initial treatment (responders); 2 showed no improvement (non-responders). No electrophysiological measure changed after treatment in either group but MUNEs trended higher (P = 0.055). "Abnormal A-waves" (complex, repetitive biphasic, or present in multiple nerves) occurred in pretreatment studies more often in responders (P = 0.028).DISCUSSION:
"Abnormal A-waves" may signal IVIg-responsive LMN syndromes even if conduction block is absent.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Polineuropatías
/
Inmunoglobulinas Intravenosas
/
Fuerza Muscular
/
Conducción Nerviosa
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Muscle Nerve
Año:
2011
Tipo del documento:
Article