Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors.
Bioorg Med Chem
; 19(6): 1924-9, 2011 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-21353568
ABSTRACT
Various 5-amino group-substituted indeno[1,2-c]isoquinolines 7a-f were synthesized based on the previous QSAR study as rigid structures of 3-arylisoquinolines. Amino group-substituted compounds, especially 5-piperazinyl indeno[1,2-c]isoquinoline 7f, displayed potent topoisomerase I inhibitory activity as well as cytotoxicities against five different tumor cell lines. A Surflex-Dock docking model of 7f was also studied.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Piperazinas
/
ADN-Topoisomerasas de Tipo I
/
Inhibidores de Topoisomerasa I
/
Isoquinolinas
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article