Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.
Nat Neurosci
; 14(4): 411-3, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21378973
ABSTRACT
SNARE proteins mediate membrane fusion. Neurosecretion depends on neuronal soluble NSF attachment protein receptors (SNAREs; SNAP-25, syntaxin-1, and synaptobrevin-1 or synaptobrevin-2) and is blocked by neurotoxin-mediated cleavage or genetic ablation. We found that exocytosis in mouse inner hair cells (IHCs) was insensitive to neurotoxins and genetic ablation of neuronal SNAREs. mRNA, but no synaptically localized protein, of neuronal SNAREs was present in IHCs. Thus, IHC exocytosis is unconventional and may operate independently of neuronal SNAREs.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Proteínas SNARE
/
Exocitosis
/
Células Ciliadas Auditivas Internas
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2011
Tipo del documento:
Article