Depression and glycemic intake in the homebound elderly.
J Affect Disord
; 132(1-2): 94-8, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21396718
ABSTRACT
BACKGROUND:
Depression is associated with an increase in the incidence of type 2 diabetes, but the mechanism is unclear. We aimed to study the relationship between depression and glycemic intake in the elderly, and examine whether antidepressant use modified this relationship. DESIGN, SETTING ANDPARTICIPANTS:
We evaluated 976 homebound elders in a cross-sectional study. Depression was defined by having a Center for Epidemiological Studies Depression (CES-D) score ≥16. Antidepressant use was documented. Glycemic index (GI), Glycemic load (GL), and fasting blood insulin levels were measured.RESULTS:
Depressed elders had slightly higher GI (Mean±SD 55.8±3.8 vs. 55.1±3.7, P=0.003) and higher insulin levels (Median 84.0 vs. 74.4pmol/ml, P=0.05) than non-depressed elders. Depressed elders receiving antidepressants, primarily selective serotonin reuptake inhibitors (SSRI), had lower GI (Mean±SD 55.1±4.7 vs. 56.2±3.4, P=0.002) and GL (Median 170.3 vs. 6826.3, P=0.03) than those not taking antidepressants. After adjusting for potential confounding variables, GI remained positively associated with depression (ß=+0.65, SE=0.28, P=0.02); the logarithm of GL was positively associated with depression (ß=+0.33, SE=0.17, P=0.05) and negatively associated with antidepressant use (ß=-0.54, SE=0.18, P=0.003).CONCLUSIONS:
Prospective studies are needed to examine whether high glycemic intake is a mediating factor between late life depression and the risk of type 2 diabetes.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carbohidratos de la Dieta
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Personas Imposibilitadas
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Índice Glucémico
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Trastorno Depresivo
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Diabetes Mellitus Tipo 2
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Conducta Alimentaria
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Insulina
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Affect Disord
Año:
2011
Tipo del documento:
Article