Effects of cigarette smoking on lipid peroxidation and antioxidant status in cancer patients from Western Nepal.

ABSTRACT

OBJECTIVES: There is growing evidence that oxidative stress (OS) has a causal relationship with cancer and a weak antioxidant defense can aggravate it further. We therefore, undertook this study to examine lipid peroxidation (TBARS), total antioxidant activity (TAA), ascorbic acid (vitamin C) and α- tocopherol levels in cancer patients, with special attention to the influence of smoking. METHODS: The study subjects were 42 patients (61.19 ± 10.1 yrs) suffering from cancer and 43 normal subjects (NS) (56.69 ± 19.1 yrs). Plasma levels of TBARS, TAA, vitamin C and ?- tocopherol were estimated. RESULTS: TAA and α-tocopherol levels were significantly lower and TBARS levels significantly higher in cancer patients when compared to NS. In smoking cancer patient's ?-tocopherol levels were significantly low and TBARS significantly raised. CONCLUSION: Our observations indicate that increased lipid peroxidation, reduced total antioxidant activity and ?-tocopherol levels are associated with cancer development, with and without smoking. However, a greater reduction of TAA in smokers may be due to increased oxidants introduced by smoking.