[201Thalium SPECT in the detection of recurrent laryngeal carcinoma]. / El SPECT con (201)Talio en la detección de recidiva del carcinoma de laringe.
Rev Esp Med Nucl
; 30(4): 236-40, 2011.
Article
en Es
| MEDLINE
| ID: mdl-21546128
ABSTRACT
OBJECTIVE:
To evaluate the diagnostic yield of (201)Thallium SPECT in the detection of local and/or regional lymph node dissemination of pharyngolaryngeal carcinoma. MATERIAL ANDMETHODS:
29 patients who had been diagnosed with pharyngolaryngeal carcinoma were studied (mean age 60.9 years). These patients had been treated by surgery, chemotherapy and radiotherapy. At between 3 to 6 month after finishing the treatment, all of them underwent a planar and SPECT study at one hour after the administration of 148 MBq of (201)Thallium. Uptake was scored on four grades from 0 (no uptake) to 3 (very intense uptake). The presence or non-presence of lymph nodes with uptake was also evaluated. All the results on the scintigraphy were correlated with long term clinical and radiological follow-up (mean 2.5 years). The studies were classified as positive for recurrence when the uptake was 2-3 and/or with presence of lymph nodes with uptake.RESULTS:
We obtained 9 true positive, 14 true negative, 3 false positive and 3 false negative results. Sensitivity was 75%, specificity was 82.4%, positive predictive value was 75% and negative predictive value was 82.4%. Two out of three false positives corresponded to the surgical bed uptake and one was attributed to the laterocervical lymph nodes. The three false negatives had grade 1 uptakes, two of them corresponding to pulmonary metastasis without evidence of local recurrence.CONCLUSIONS:
The use of (201)Thallium SPECT in the prognostic evaluation in patients with a treated laryngeal carcinoma shows very acceptable results in the detection of local recurrence and/or regional lymph node dissemination.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Radioisótopos de Talio
/
Carcinoma de Células Escamosas
/
Tomografía Computarizada de Emisión de Fotón Único
/
Neoplasias Laríngeas
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Es
Revista:
Rev Esp Med Nucl
Asunto de la revista:
MEDICINA NUCLEAR
Año:
2011
Tipo del documento:
Article