Management of the cancer patient with infection and neutropenia.
Semin Oncol
; 38(3): 424-30, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21600373
ABSTRACT
Infections are major causes of morbidity and mortality in cancer. The intensity and duration of immunosuppressive chemotherapy determine the risk. Cancer may be associated with immune defects, in particular hematologic malignancies. Predisposing factors include tumor site, intravenous devices, neutropenia due to underlying disease, mucosal lesions, corticosteroids, monoclonal antibodies, splenic dysfunction, and treatment with chemotherapy or radiation therapy. Bacteremia is documented in approximately 25% of people with febrile neutropenia. The drug choice for empiric therapy is influenced by factors related either to the patient or to the institution. Guidelines and general statements should always take local epidemiology into consideration. The therapeutic hematopoietic growth factors should be reserved for patients with fever and neutropenia and those at high risk for infection-associated complications or poor clinical outcomes. The Multinational Association of Supportive Care in Cancer (MASCC) has developed a Risk Index that predicts the risk of medical complications and outcome.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Factores de Crecimiento de Célula Hematopoyética
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Infecciones
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Antibacterianos
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Antifúngicos
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Neoplasias
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Neutropenia
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Guideline
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Semin Oncol
Año:
2011
Tipo del documento:
Article