A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma.
BMC Cancer
; 11: 209, 2011 May 29.
Article
en En
| MEDLINE
| ID: mdl-21619704
ABSTRACT
BACKGROUND:
Osteosarcoma (OS) is a bone malignancy which occurs primarily in adolescents. Since it occurs during a period of rapid growth, genes important in bone formation and growth are plausible modifiers of risk. Genes involved in DNA repair and ribosomal function may contribute to OS pathogenesis, because they maintain the integrity of critical cellular processes. We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways.METHODS:
We evaluated 4836 tag-SNPs across 255 candidate genes in 96 OS cases and 1426 controls. Logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CI).RESULTS:
Twelve SNPs in growth or DNA repair genes were significantly associated with OS after Bonferroni correction. Four SNPs in the DNA repair gene FANCM (ORs 1.9-2.0, P = 0.003-0.004) and 2 SNPs downstream of the growth hormone gene GH1 (OR 1.6, P = 0.002; OR 0.5, P = 0.0009) were significantly associated with OS. One SNP in the region of each of the following genes was significant MDM2, MPG, FGF2, FGFR3, GNRH2, and IGF1.CONCLUSIONS:
Our results suggest that several SNPs in biologically plausible pathways are associated with OS. Larger studies are required to confirm our findings.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Neoplasias Óseas
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Osteosarcoma
/
Polimorfismo de Nucleótido Simple
/
Estudios de Asociación Genética
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
BMC Cancer
Asunto de la revista:
NEOPLASIAS
Año:
2011
Tipo del documento:
Article