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Identifying the trigger of c-IAPs: structural and functional characterization of CARD-mediated modulation of ubiquitin ligase activity.
Oetjen, Karolyn A; Duckett, Colin S.
Afiliación
  • Oetjen KA; Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mol Cell ; 42(5): 553-4, 2011 Jun 10.
Article en En | MEDLINE | ID: mdl-21658595
In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which conformational changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulation of cell proliferation and survival by the IAPs.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2011 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2011 Tipo del documento: Article