Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-21705217
ABSTRACT
Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38α have been prepared exploring functional group modifications at the C6 position. Incorporation of aryl and heteroaryl ketones at this position led to potent inhibitors with efficacy in in vivo models of acute and chronic inflammation.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pirroles
/
Triazinas
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Proteína Quinasa 14 Activada por Mitógenos
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Inhibidores de Proteínas Quinasas
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Antiinflamatorios
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article