New antimicrobial frontiers.
Mini Rev Med Chem
; 11(10): 888-900, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21781024
ABSTRACT
New antimicrobials able to counteract bacterial resistance are needed to maintain the control of infectious diseases. The last 40 years have seen the systematic tailoring and refinement of previously identified antibiotics, to produce a multitude of semi-synthetic derivatives that share their mechanism of action with the original molecules. The major limit of this approach is the emergence of multi- and cross-resistant bacterial strains, favoured by the selective pressure inherent to the targeting of specific enzymes. The most promising new strategies aim to the development of molecules that, targeting essential bacterial structures instead of specific enzymatic activities, achieve infection control without enforcing a selective pressure on bacteria. This review, based on the consultation of the up-to-date literature, deals with antimicrobial peptides and some antivirulence factors.
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Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Antiinfecciosos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Mini Rev Med Chem
Asunto de la revista:
QUIMICA
Año:
2011
Tipo del documento:
Article