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Angiogenesis in skeletal muscle precede improvements in peak oxygen uptake in peripheral artery disease patients.
Duscha, Brian D; Robbins, Jennifer L; Jones, William S; Kraus, William E; Lye, R John; Sanders, John M; Allen, Jason D; Regensteiner, Judith G; Hiatt, William R; Annex, Brian H.
Afiliación
  • Duscha BD; Duke University Medical Center, Division of Cardiology, Durham, NC 27710, USA. brian.duscha@duke.edu
Arterioscler Thromb Vasc Biol ; 31(11): 2742-8, 2011 Nov.
Article en En | MEDLINE | ID: mdl-21868709
OBJECTIVE: Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. The mechanism(s) by which exercise training improves functional capacity is not understood. This study tested the hypothesis that in PAD patients who undergo supervised exercise training, increases in capillary density (CD) in calf muscle take place before improvements in peak oxygen uptake (VO(2)). METHODS AND RESULTS: Thirty-five PAD patients were randomly assigned to 12 weeks of directly supervised or home-based exercise training. Peak VO(2) testing and gastrocnemius muscle biopsies were performed at baseline and after training. CD (endothelial cells/mm(2)) was measured using immunofluorescence staining. After 3 weeks of directly supervised training, patients had an increase in CD (216±66 versus 284±77, P<0.01) but no increase in peak VO(2). However, after 12 weeks, peak VO(2) increased (15.3±2.8 versus 16.8±3.8, P<0.01), whereas in muscle, CD remained increased over baseline, but there were no changes in markers of oxidative capacity. Within subjects, CD was related to peak VO(2) before and after directly supervised training. CONCLUSION: Changes in CD in ischemic muscle with training may modulate the response to training, and those changes precede the increase in VO(2).
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Músculo Esquelético / Neovascularización Fisiológica / Terapia por Ejercicio / Enfermedad Arterial Periférica Tipo de estudio: Clinical_trials Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2011 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Músculo Esquelético / Neovascularización Fisiológica / Terapia por Ejercicio / Enfermedad Arterial Periférica Tipo de estudio: Clinical_trials Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2011 Tipo del documento: Article