Long-chain lipids are required for the innate immune recognition of trehalose diesters by macrophages.

Khan, Ashna A; Chee, Stephanie H; McLaughlin, Rene J; Harper, Jacquie L; Kamena, Faustin; Timmer, Mattie S M; Stocker, Bridget L

Khan, Ashna A; Chee, Stephanie H; McLaughlin, Rene J; Harper, Jacquie L; Kamena, Faustin; Timmer, Mattie S M; Stocker, Bridget L.

Afiliación

Khan AA; Malaghan Institute of Medical Research, Wellington 6242, New Zealand.

Chembiochem ; 12(17): 2572-6, 2011 Nov 25.

Article en En | MEDLINE | ID: mdl-21990105

RESUMEN

Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO and cytokine production by macrophages. In this work, we show that longer lipids (C(20) -C(26)) are required for macrophage activation, with C(22) giving optimal activity.

Asunto(s)

Inmunidad Innata; Lípidos/química; Macrófagos/metabolismo; Trehalosa/química; Animales; Factores Cordón/química; Factores Cordón/inmunología; Citocinas/metabolismo; Lípidos/inmunología; Activación de Macrófagos; Macrófagos/inmunología; Masculino; Ratones; Ratones Endogámicos C57BL; Óxido Nítrico/metabolismo; Trehalosa/inmunología

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trehalosa / Inmunidad Innata / Lípidos / Macrófagos Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2011 Tipo del documento: Article

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