Structural insights into regulation and action of SWI2/SNF2 ATPases.
Curr Opin Struct Biol
; 21(6): 719-27, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21996440
This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Adenosina Trifosfatasas
/
Proteínas de Unión al ADN
Idioma:
En
Revista:
Curr Opin Struct Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2011
Tipo del documento:
Article