Regression of early diabetic macular oedema is associated with prevention of dark adaptation.
Eye (Lond)
; 25(12): 1546-54, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22020171
ABSTRACT
HYPOTHESIS:
Dark-adapted rods consume oxygen at high rates and light adaptation decreases this oxygen burden and can have therapeutic effects on diabetic macular oedema (DMO).METHODS:
Patients with mild non-proliferative diabetic retinopathy (DR) and early, untreated non-sight-threatening DMO slept for 6 months wearing masks that illuminated the eyelid of one closed eye by 505 nm light. Exclusion criteria were any concomitant eye disease, DR >ETDRS grade 35, and other systemic diseases. PRIMARYOUTCOME:
change of OCT retinal thickness in the local region where oedema was present.RESULTS:
A total of 34 out of 40 patients completed the study. Mean baseline OCT macular cube thickness was equivalent for study and fellow eyes. But study eyes had a greater mean thickness in the central subfield zone 1 (282±53 µm) vs (256±19 µm) the fellow eyes. Twenty-eight study eyes showed intraretinal cysts compared with nine in the fellow eyes. At 6 months, only 19 study eyes had cysts while cysts were seen in 20 fellow eyes. After 6 months, the worst affected ETDRS zone and the central subfield zone 1 reduced in thickness in study eyes only by 12 µm (95% CI 20 to -7, P=0.01). The secondary outcomes of change in visual acuity, achromatic contrast sensitivity, and microperimetric thresholds improved significantly in study eyes and deteriorated in fellow eyes.CONCLUSIONS:
Sleeping in dim light that can keep rods light adapted may reverse the changes of DMO.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fototerapia
/
Retina
/
Edema Macular
/
Células Fotorreceptoras Retinianas Bastones
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Adaptación a la Oscuridad
/
Retinopatía Diabética
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Eye (Lond)
Asunto de la revista:
OFTALMOLOGIA
Año:
2011
Tipo del documento:
Article