Distribution of spontaneous gyrA mutations in 97 fluoroquinolone-resistant Helicobacter pylori isolates collected in France.
Antimicrob Agents Chemother
; 56(1): 550-1, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22064536
ABSTRACT
We determined the prevalence of gyrA mutations conferring fluoroquinolone resistance in 97 Helicobacter pylori isolates collected in France from 2007 to 2010. Ninety-four harbored one or two mutations already found in the quinolone resistance determining region (QRDR) of gyrA (for T87I, n = 23; for N87K, n = 32; for D91N, n = 30; for D91G, n = 7; for D91Y, n = 6), 2 harbored a mutation never previously described (D91H and A88P), and one strain was resistant (ciprofloxacin MIC of 8 mg/liter) without a detected mutation conferring this resistance in gyrA or gyrB genes.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ciprofloxacina
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Girasa de ADN
Tipo de estudio:
Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2012
Tipo del documento:
Article