Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample.
J Clin Exp Neuropsychol
; 33(10): 1059-68, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22133139
ABSTRACT
Performance on measures of cognitive processing speed (CPS) slows with age, but the biological basis associated with this cognitive phenomenon remains incompletely understood. We assessed the hypothesis that the age-related slowing in CPS is associated with myelin breakdown in late-myelinating regions in a very healthy elderly population. An in vivo magnetic resonance imaging (MRI) biomarker of myelin integrity was obtained from the prefrontal lobe white matter and the genu of the corpus callosum for 152 healthy elderly adults. These regions myelinate later in brain development and are more vulnerable to breakdown due to the effects of normal aging. To evaluate regional specificity, we also assessed the splenium of the corpus callosum as a comparison region, which myelinates early in development and primarily contains axons involved in visual processing. The measure of myelin integrity was significantly correlated with CPS in highly vulnerable late-myelinating regions but not in the splenium. These results have implications for the neurobiology of the cognitive changes associated with brain aging.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Trastornos del Conocimiento
/
Cuerpo Calloso
/
Procesos Mentales
/
Fibras Nerviosas Mielínicas
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Clin Exp Neuropsychol
Asunto de la revista:
NEUROLOGIA
/
PSICOLOGIA
Año:
2011
Tipo del documento:
Article