Factors of impact on graft function at 2 years after transplantation in living-donor kidney transplantation: a single-center study in china.

OBJECTIVE: The aim was to investigate the factors that affect graft function at 2 years after transplantation in living related-donor kidney transplantation. METHODS: We retrospectively reviewed the clinical data of 144 patients who underwent living related-donor kidney transplantation in our hospital from December 2005 to December 2008. Recipients were divided into 2 groups according to glomerular filtration rate (GFR) at 2 years after transplantation: ≤60 mL/min/1.73 m2 (n=51) and >60 mL/min/1.73 m2 (n=93). Variables which affected graft function were compared between the groups. The significant factors were analyzed using logistic regression. RESULTS: Univariate analysis showed significant differences for donor age, donor GFR, recipient weight, recipient body mass index, donor-to-recipient body weight ratio, and acute rejection episodes (P<.05). Logistic regression analysis revealed the independent factors affecting renal function at 2 years after transplantation to be donor GFR (ß=0.032; odds ratio [OR] 1.032; P=.004) and recipient body weight (ß=-0.069; OR 0.934; P=.001). Receiver operating characteristic (ROC) curve analysis showed cutoff values of donor GFR and recipient body weight to be >111.25 mL/min/1.73 m2, and ≤67 kg, respectively. Areas under the ROC curve of donor GFR and recipient body weight were 0.612 and 0.665, respectively. Sensitivity and specificity of donor GFR were 43.0% and 78.4%, respectively. Sensitivity and specificity of recipient body weight were 82.8% and 45.1%, respectively. CONCLUSIONS: Donor GFR and recipient body weight were the independent factors effecting renal function at 2 years after transplantation.