Immunogenic epitopes of Hantaviruses' N protein are restricted to conserved regions.
Front Biosci (Landmark Ed)
; 17(4): 1582-8, 2012 01 01.
Article
en En
| MEDLINE
| ID: mdl-22201821
ABSTRACT
The Bunyaviridae virus family is composed by five genera, of which the Hantavirus genus is one of the most important representatives. Occasionally, these viruses can be transmitted to humans, giving rise to severe diseases that present high mortality rates. We analyzed the amino acid sequences of the nucleocapsid (N) proteins of 34 different hantaviruses to investigate the potential mechanisms involved in immunogenicity against hantaviruses. Immunogenic epitopes described in the literature through experimental analyses for Sin Nombre (SNV), Puumala (PUUV), and Hantaan (HTNV) viruses' species were retrieved. We identified and characterized the regions believed to be responsible for the induction of immune response in hosts. We found that N protein epitopes described in the literature for PUUV, SNV and HTNV viruses are all located in highly conserved regions of the protein. The high conservation of these regions suggests that a cross-reactive immune response among different hantaviruses can be induced.
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Base de datos:
MEDLINE
Asunto principal:
Proteínas del Núcleo Viral
/
Orthohantavirus
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Secuencia Conservada
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Proteínas de la Cápside
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Epítopos
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Año:
2012
Tipo del documento:
Article