Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.

Tuncel, Sinem; Fournier-dit-Chabert, Jérémie; Albrieux, Florian; Ahsen, Vefa; Ducki, Sylvie; Dumoulin, Fabienne

Tuncel, Sinem; Fournier-dit-Chabert, Jérémie; Albrieux, Florian; Ahsen, Vefa; Ducki, Sylvie; Dumoulin, Fabienne.

Afiliación

Tuncel S; Department of Chemistry, Gebze Institute of Technology, P.O. Box 141, 41400 Gebze Kocaeli, Turkey. ahsen@gyte.edu.tr fdumoulin@gyte.edu.tr.

Org Biomol Chem ; 10(6): 1154-7, 2012 Feb 14.

Article en En | MEDLINE | ID: mdl-22215066

ABSTRACT

ABSTRACT

A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(ii) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.

Asunto(s)

Inhibidores de la Angiogénesis/síntesis química; Diseño de Fármacos; Indoles/química; Compuestos Organometálicos/química; Fármacos Fotosensibilizantes/síntesis química; Inhibidores de la Angiogénesis/química; Chalcona/análogos & derivados; Chalcona/química; Isoindoles; Estructura Molecular; Fármacos Fotosensibilizantes/química; Estereoisomerismo; Compuestos de Zinc

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Diseño de Fármacos / Fármacos Fotosensibilizantes / Inhibidores de la Angiogénesis / Indoles Tipo de estudio: Prognostic_studies Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2012 Tipo del documento: Article

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