Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse.
Immunol Lett
; 144(1-2): 1-6, 2012 May 30.
Article
en En
| MEDLINE
| ID: mdl-22387632
ABSTRACT
Toll-like receptors appear to play an important role in the pathogenesis of lupus-like nephritis in mice. In human and mouse, CD180 is a homologue of TLR4. In SLE patients, the number of CD180-negative B cells in peripheral blood changes in parallel with disease activity. In the present study using NZBWF1 mice, the population of splenic CD180-negative B cells increased with progression of renal lesions and aging. These cells produced both anti-dsDNA and histone antibodies; the peripheral blood levels of anti-dsDNA antibody increased markedly with aging. B cells infiltrating into renal lesions were CD180-negative and produced anti-dsDNA antibody. Considered together, these findings indicate that CD180-negative B cells contribute significantly to development of SLE-like morbidity in NZBWF1 mice by autoantibody production.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
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Enfermedades Autoinmunes
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Nefritis Lúpica
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Linfocitos B
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Antígenos CD
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Immunol Lett
Año:
2012
Tipo del documento:
Article