Effects of the protein synthesis inhibitor cycloheximide on anxiety-like extinction behavior in an animal model of post-traumatic stress.
Behav Brain Res
; 231(1): 208-12, 2012 May 16.
Article
en En
| MEDLINE
| ID: mdl-22465354
ABSTRACT
The effect of cycloheximide (CXM), a protein synthesis inhibitor, on memory reconsolidation and extinction was explored in rats using a model of post-traumatic stress. Forty-two animals were exposed to predator stress followed by 1, 2, or 4 extinction trials. Saline or CXM (1 mg/kg) was administered following the last extinction trial and anxiety was measured in the elevated-plus maze (EPM) seventy-two hours later. Saline control animals exhibited elevated anxiety levels in comparison to a no stress control group. Cycloheximide appeared to maintain stress-induced anxiety responses, which otherwise declined with repeated extinction trials in the saline control groups. These findings suggest that cycloheximide may have induced amnesia for extinction, leaving the target memory of the predatory stress intact resulting in elevated levels of anxiety. The relationships between de novo protein synthesis and reconsolidation of anxiety-related memories following extinction trials may be more complex than originally thought.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ansiedad
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Trastornos por Estrés Postraumático
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Conducta Animal
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Inhibidores de la Síntesis de la Proteína
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Cicloheximida
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Extinción Psicológica
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Behav Brain Res
Año:
2012
Tipo del documento:
Article