Molecular findings of nasopharyngeal carcinoma in a European population.
Anal Quant Cytol Histol
; 33(6): 316-22, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22590809
ABSTRACT
OBJECTIVE:
To explore biomolecular characteristics of a group of patients with nasopharyngeal carcinoma from European (Spanish) hospitals, addressing the pathogenesis of the tumor and the response to treatment. STUDYDESIGN:
Cyclin D1 and p16 expression were evaluated immunohistochemically in 33 tissue samples of nasopharyngeal carcinoma. CCDN1 gene amplification and p16 gene deletion were studied by fluorescence in situ hybridization. Patient clinical data were examined, and tissues were evaluated histologically using hematoxylin-eosin staining.RESULTS:
Cyclin D1 overexpression was found in 19 cases, and p16 expression was undetected in 30 cases. An association was observed between impaired p16 expression and cyclin D1 overexpression (p = 0.034). Eleven patients displayed p16 gene deletion and CCDN1 gene amplification.CONCLUSION:
Cyclin D1 overexpression and CCDN1 amplification, loss of p16 expression and p16 deletion may be among the genetic alterations involved in the pathogenesis of nasopharyngeal carcinoma.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Nasofaríngeas
/
Ciclina D1
/
Inhibidor p16 de la Quinasa Dependiente de Ciclina
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Anal Quant Cytol Histol
Asunto de la revista:
HISTOLOGIA
Año:
2011
Tipo del documento:
Article