Decisional procalcitonin thresholds are not adapted to elderly patients admitted to the emergency room.
Biomarkers
; 17(5): 477-81, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22607374
ABSTRACT
CONTEXT Diagnosis of sepsis in elderly is challenging. OBJECTIVES:
We investigated whether procalcitonin concentrations in elderly differed from values for the general population.METHODS:
Procalcitonin measurement was assessed prospectively in 307 apyretic patients ≥75 years visiting the emergency department.RESULTS:
Median age was 86 years [IQR81-90] and 222 (72%) were female. Procalcitonin concentration was 0.057 µg/L [0.040-0.092]; 99th percentile was 0.661 µg/L. Patients with procalcitonin concentrations above decisional thresholds had lower glomerular filtration rate and higher C-reactive protein concentrations.CONCLUSIONS:
Baseline procalcitonin levels are increased in elderly. Elevated values are common and associated to low-grade inflammation and lower eGFR.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
Proteína C-Reactiva
/
Calcitonina
/
Servicio de Urgencia en Hospital
/
Tasa de Filtración Glomerular
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Biomarkers
Asunto de la revista:
BIOQUIMICA
Año:
2012
Tipo del documento:
Article