Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction.
J Biomed Opt
; 17(5): 058003, 2012 May.
Article
en En
| MEDLINE
| ID: mdl-22612150
ABSTRACT
When irradiated with nanosecond laser pulses, gold nanoparticles allow for manipulation or destruction of cells and proteins with high spatial and temporal precision. Gold nanorods are especially attractive, because they have an up-to-20-fold stronger absorption than a sphere of equal volume, which is shifted to the optical window of tissue. Thus, an increased efficiency of cell killing is expected with laser pulses tuned to the near infrared absorption peak of the nanorods. In contrast to the higher-absorption, experiments showed a reduced efficacy of cell killing. In order to explain this discrepancy, transient absorption of irradiated nanorods was measured and the observed change of particle absorption was theoretically analyzed. During pulsed irradiation a strong transient and permanent bleaching of the near-infrared absorption band occurred. Both effects limit the ability of nanorods to destroy cells by nanocavitation. The existence of nanocavitation and transient bleaching was corroborated by optoacoustic measurements.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fraccionamiento Celular
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Nanotubos
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Oro
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Rayos Láser
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Linfoma
Idioma:
En
Revista:
J Biomed Opt
Asunto de la revista:
ENGENHARIA BIOMEDICA
/
OFTALMOLOGIA
Año:
2012
Tipo del documento:
Article